| Date | Opponent | Location | Outcome/Time |
| 02/02/2001 | Auburn | Auburn, Ala. | L, 14-1 Recap | Stats |
| 02/03/2001 | Auburn | Auburn, Ala. | L, 4-2 Recap | Stats |
| 02/04/2001 | Auburn | Auburn, Ala. | L, 5-4 Recap | Stats |
| 02/09/2001 | East Carolina | Greenville, NC | L, 9-5 Recap | Stats |
| 02/10/2001 | East Carolina | Greenville, NC | L, 6-0 Recap | Stats |
| 02/11/2001 | East Carolina | Greenville, NC | L, 12-1 Recap | Stats |
| 02/17/2001 | Wright State | Cullowhee, NC | W, 15-2 Recap | Stats |
| 02/18/2001 | Wright State (Game 1) | Cullowhee, NC | L, 13-12 Stats |
| 02/18/2001 | Wright State (Game 2) | Cullowhee, NC | W, 10-6 Recap | Stats |
| 02/23/2001 | Kent State (Coastal Carolina Tourney) | Conway, SC | W, 9-5 Recap | Stats |
| 02/24/2001 | Coastal Carolina (Coastal Carolina Tourney) | Conway, SC | L, 13-2 Recap | Stats |
| 02/25/2001 | Delaware (Coastal Carolina Tourney) | Conway, SC | W, 7-6 Recap | Stats |
| 02/28/2001 | UNC Asheville | Cullowhee, N.C. | W, 19-10 Recap | Stats |
| 03/03/2001 | Wofford* (Rained Out) | Spartanburg, SC | Stats |
| 03/04/2001 | Wofford (Game 1)* | Spartanburg, S.C. | W, 10-1 Recap | Stats |
| 03/04/2001 | Wofford (Game 2)* | Spartanburg, SC | L, 5-4 Recap | Stats |
| 03/07/2001 | UNC Asheville | Cullowhee, NC | W, 9-7 Recap | Stats |
| 03/09/2001 | College of Charleston* | Charleston, SC | L, 3-2 Recap | Stats |
| 03/10/2001 | College of Charleston* | Charleston, SC | W, 7-3 Recap | Stats |
| 03/11/2001 | College of Charleston* | Charleston, SC | L, 5-2 Recap | Stats |
| 03/14/2001 | Tennessee | Knoxville, Tenn. | L, 6-3 Recap | Stats |
| 03/16/2001 | UNC Greensboro* | Cullowhee, NC | W, 10-1 Recap | Stats |
| 03/17/2001 | UNC Greensboro* | Cullowhee, NC | L, 22-5 Recap | Stats |
| 03/18/2001 | UNC Greensboro* | Cullowhee, NC | W, 11--9 Recap | Stats |
| 03/23/2001 | Georgia Southern* | Cullowhee, NC | W, 13-12 Recap | Stats |
| 03/24/2001 | Georgia Southern* | Cullowhee, NC | L, 17-3 Recap | Stats |
| 03/25/2001 | Georgia Southern* | Cullowhee, NC | W, 13-8 Recap | Stats |
| 03/27/2001 | Tennessee | Cullowhee, NC | L, 15-13 Recap | Stats |
| 03/31/2001 | Appalachian State (Game 1)* | Cullowhee, NC | W, 7-3 Recap | Stats |
| 03/31/2001 | Appalachian State (Game 2)* | Cullowhee, NC | W, 18-7 Recap | Stats |
| 04/01/2001 | Appalachian State* | Cullowhee, NC | L, 13-11 (10) Recap | Stats |
| 04/03/2001 | Clemson (rained out) | Cullowhee, NC | 3:00 PM ET
|
| 04/06/2001 | The Citadel* | Charleston, SC | L, 7-0 Recap | Stats |
| 04/07/2001 | The Citadel* | Charleston, SC | W, 7-6 Recap | Stats |
| 04/08/2001 | The Citadel* | Charleston, SC | W, 12-6 Recap | Stats |
| 04/10/2001 | Georgia State | Atlanta, Ga. | L, 4-3 Recap | Stats |
| 04/11/2001 | Georgia State | Atlanta, Ga. | W, 13-7 Recap | Stats |
| 04/13/2001 | East Tennessee State* | Cullowhee, NC | W, 9-8 Recap | Stats |
| 04/14/2001 | East Tennessee State* | Cullowhee, NC | L, 9-5 Recap | Stats |
| 04/15/2001 | East Tennessee State* | Cullowhee, NC | W, 8-7 Recap | Stats |
| 04/18/2001 | UNC Asheville | Asheville, NC | W, 16-1 Recap | Stats |
| 04/20/2001 | Furman* | Greenville, SC | L, 11-8 Recap | Stats |
| 04/21/2001 | Furman* | Greenville, SC | L, 6-1 Recap | Stats |
| 04/22/2001 | Furman* | Greenville, SC | W, 7-5 Recap | Stats |
| 04/24/2001 | Clemson | Clemson, SC | L, 8-2 Recap | Stats |
| 04/28/2001 | N.C. A&T (Game 1) | Cullowhee, NC | W, 13-12 Recap | Stats |
| 04/28/2001 | N.C. A&T (Game 2) | Cullowhee, NC | W, 18-4 Stats |
| 04/29/2001 | N.C. A&T | Cullowhee, NC | W, 9-3 Recap | Stats |
| 05/01/2001 | Georgia | Athens, Ga. | L, 7-2 Recap | Stats |
| 05/02/2001 | UNC Asheville | Asheville, NC | W, 5-4 Recap | Stats |
| 05/05/2001 | Davidson (Game 1)* | Cullowhee, NC | W, 8-7 Recap | Stats |
| 05/05/2001 | Davidson (Game 2)* | Cullowhee, N.C. | W, 13-7 Stats |
| 05/06/2001 | Davidson* | Cullowhee, NC | W, 7-0 Recap | Stats |
| 05/12/2001 | VMI (Game 1)* | Lexington, Va. | W, 5-3 Recap |
| 05/12/2001 | VMI (Game 2)* | Lexington, Va. | L, 15-8 Stats |
| 05/13/2001 | VMI* | Lexington, Va. | W, 6-3 Recap | Stats |
| 05/16/2001 | UNC Greensboro (SoCon Tourney) | Charleston, SC | L, 7-5 Recap | Stats |
| 05/17/2001 | College of Charleston (SoCon Tourney) | Charleston, SC | L, 9-7 Recap | Stats |